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Abstract
Androgens are C-19 steroid hormones with androgenic and
anabolic effects. Hyperandrogenism or androgen excess can occur due to
overproduction of androgens from the ovaries (PCOS, tumours, stromal
hyperthecosis, luteoma of pregnancy) or adrenal glands(congenital
adrenal hyperplasia, Cushing’s syndrome, and androgens producing
tumours). Drugs and other miscallaneous causes also play a role.
Hyperandrogenism can present in many clinical syndromes. These
include: ambiguous genitalia, abnormal sexual development and
differentiation, abnormal puberty, anovulation and PCO, Hirsutism and
disorders of menstruation. Laboratory evaluation consists of assays for
the blood levels of these hormones treatment includes medical therapy to
suppress abnormal ovarian or adrenal androgen production or medical
therapy to block androgen offects at the end organ. Surgery may have a
role in selected cases