الفهرس | Only 14 pages are availabe for public view |
Abstract Aim of the work Is to examine whether, on the basis of neopterin as a marker, liver diseases could be classified according to etiology and stage of disease. Also, whether neopterin concentrations could be correlated with other laboratory and clinical parameters. Conclusion 1- Liver diseases represent major and complicated health problem in childhood. There are many etiologic factors associated with liver diseases e.g. infections, genetic, vascular, toxic …etc. 2- Viral hepatitis is the most prevalent factor of liver disease among Egyptian children. 3- Activated macrophages participate in liver disease, progressing to cirrhosis. 4- Neopterin is a marker for immune activation. 5- Liver function tests are usually within normal in most cases with liver diseases; this reflects the large functional reserve of the liver so it can tolerate minimal or even moderate cell injury. 6- Neopterin serum level is usually higher in most cases with liver disease. 7- Neopterin serum level is significantly increased in acute liver disease. 8- Neopterin serum level is highly significant in both chronic cirrhotic and chronic non cirrhotic liver diseases. |