الفهرس | Only 14 pages are availabe for public view |
Abstract The aim of the work is to study the activity of antioxidant enzymes; superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in both type 1 and type 2 diabetes mellitus with and without retinopathy, in an attempt to find out if these antioxidant enzymes could have a relation to diabetic retinopathy, we also want to study the levels of oxidized LDL in diabetes mellitus to clarify its possible association with diabetic retinopathy. The following results were obtained: Comparing each diabetic group with the normal control group: - There were very highly significant elevation of total cholesterol, triglycerides, and LDL-cholesterol in both diabetic groups than the normal controls, and a significant decrease in HDL-cholesterol. - Oxidized IDL were significantly higher in both diabetic groups than the normal control group. - The 3 antioxidant enzymes; SOD, CAT, and GPx were significantly lower in both diabetic groups than the control group. Comparing subgroups with and without retinopathy: - Diabetes duration was significantly longer in subgroups with retinopathy in both types of diabetes. - S.B.P. and D.B.P. were significantly higher in subgroups with retinopathy but there is no significant association after doing multiple regression analysis. - HbA1c was significantly higher in subgroups with retinopathy. - Total cholesterol, triglycerides, and LDL-cholesterol were significantly higher in subgroups with retinopathy, and HDL-cholesterol was significantly lower in groups with retinopathy. - Oxidized LDL was significantly higher in subgroups with retinopathy. - The 3 antioxidant enzymes were significantly lower in subgroups with retinopathy. |