الفهرس 
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Abstract
Nonspecific gastrointestinal toxicity (nausea, vomiting, and anorexia) is common in older children and adults treated with intensified asparaginase therapy.(14,16) A relationship between high blood ammonia levels and either liver toxicity or cerebral dysfunction (e.g., encephalopathy) has not been established.(14) Azotemia occurs frequently in patients receiving L-Asp; however, they rarely experience renal failure. Patients receiving intensive asparaginase therapy may be at increased risk of developing secondary leukemias induced by topoisomerase-targeted drugs. In rare incidence, Hyperthermia (fever or chills) may occur. Also, immunosuppression and leukopenia may be marked but bone marrow depression is transient.(24)Venous thrombosis is a multifactorial disorder in which genetic and acquired risk factors may interact to determine occurrence of thrombotic events (TE).(13) With the exception of acute lymphoblastic leukemia (ALL), the knowledge about TE in childhood cancer is still limited.(35)