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Abstract
Multiple sclerosis is a chronic disease that begins most commonly in young adults .MS lesions can occur in many different parts of the CNS, so they can cause a wide variety of symptoms and signs. Headache is a wide spread problem representing one of the ten most common symptoms in general medical practices Headache is considered as a one of pain syndromes associated with multiple sclerosis. The aim of this work was to study the association between MS and headache and to evaluate the correlation between headache (in general and its different types), the clinical features of MS and MRI lesion. This study conducted on 93 patients with definite MS. Patients were evaluated clinically using rating scales: EDSS, FSS, BDI, and headache intenisty scale. We found that the headache is a common symptom in MS patients, Migraine headache may represent as an MS attack. The presence of MS plaques in the infratentorial region is associated with an increase in the headache occurrence with migraine characteristic.