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Abstract The present study was carried out to elucidate the toxic effect of the fungicide metalaxyl on blood picture, chromosomes of bone marrow cells, nucleic acid content, biochemical parameters, histopathological picture besides metalaxyl residues in rat tissues. Eighty mature albino rats were divided into two main groups each group contain fourty rats. The first group divided into thiliy(30) rats administered orally lis LOso ofmetalaxyl (l33.8 mg/kb b.wt.) three times weekly for two weeks, the rest of rats ( 10) served as control. The second group also divided into 2 sub groups, a treated group contain thirty (30) rats administered 1/10 LOso of metalaxyl (66.9 mglkb b.wt.) orally twice weekly for two months and the other ten( 1 0) rats served as control. Effect of metalaxyl on body weight: In this study we noticed that there was a decrease in the final weights of treated rats when compared to the initial weights, there was also a significant decrease in the weight of treated rats of both groups comparing with control groups. Rats administered lis LDsoof metalaxyl (133.8 mglkb b.wt.) three times weekly for two weeks showed a clear decrease in the liver weight comparing with control, this decrease was also obvious in rats administered I I 10 LOso of metalaxyl (66.9 mglkg b.wt.) orally twice weekly for two months when compared to control at the end of the experiment. This I experiment also revealed a significant decrease in kidney weight of both treated groups in comparison to control groups. The spleen |