الفهرس 
ALLERGYOnly 14 pages are availabe for public view
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Abstract
A
llergic diseases result from an unbalanced response of the specific immune system generating allergen-specific immunoglobulin E antibodies, which mediate various clinical symptoms, such as asthma and allergic rhinitis, upon re-exposure to allergen (American Academy of Allergy, Asthma and Immunology and National Institute of Allergy and Infectious Diseases, 2007).
Immunotherapy involves repeated introduction of purified allergens, including pollens, house dust mites, fungi, and stinging insect venoms into patient body. To maximize safety and convenience, alternative routes of immunotherapy have been tried; the most promising of which is the sublingual immunotherapy (SLIT) route. This method requires administration of drops or rapidly dissolving tablets under the tongue for 2-3 minutes, usually followed by swallowing (Canonica and Passalacqua, 2003).
Recent findings are that allergen-specific regulatory T cells are induced after the initiation of specific immunotherapy and are assumed to suppress the effect of helper T cells directly mediating allergic inflammation. Therefore regulatory cells may play a key role in the reinduction of allergen tolerance (Schmidt-Weber and Blaser, 2005).