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Abstract
It has been suggested that S128R (A561C) polymorphism of E-selectin gene might be associated with the predisposition to coronary artery disease (CAD). Our aim was to study the association of the E-selectin gene mutation (Ser 128 Arg) with coronary artery disease in the Egyptian population and to evaluate the role of E-selectin gene polymorphism as a predisposing factor for atherosclerosis in Egyptian population. The polymorphism was determined in 30 CAD patients and in 20 control subjects by polymerase chain reaction followed by restriction fragment length polymorphism. The frequencies of CA, CC and AA genotypes were 16.6%, 6.6% and 76.6%, in the CAD patients and 10%,0% and 90%, in the control subjects, respectively . There was no significant difference in the frequencies of the genotypes in S128R polymorphism between the CAD and control groups.( X2=1.9 , P=0.37).
The frequency of the mutant C allele was higher among CAD patients compared to the control group( 15% vs 5%).However ,this difference was not statistically significant(X2 = 2.4, P= 0.119) .The Odds ratio for the risk of CAD associated with the C allele was OR=3.35 ;( 95% CI= 0.62 : 23.94).These results suggest that there is no association of the E-selectin gene mutation ( Ser 128 Arg) with coronary artery disease in the Egyptian population .