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Abstract
This study is based on the hypothesis that a single nucleotide polymorphism in the promoter region of Interleukin-6
gene influences its transcription and thus affects plasma level of
Interleukin-6.This will in turn lead to insulin resistance and consequently
type 2 diabetes.
This study was carried out in Kasr Al-Ainy Hospital on 60
subjects: 30 known diabetic patients (15 obese and 15 lean) and 30 nondiabetic
subjects (15 obese and 15 lean).
In the current study, serum level of Interleukin-6 was assayed by enzyme chemiluminescence and -174 G/C gene polymorphism was detected by PCR-RFLP.
Serum level of IL-6 was found to be high in the obese group, both
diabetic and non-diabetic and in the lean diabetic group. As for IL-6
genotyping, we found that 58% of the obese carrying the GG genotype
developed type 2 diabetes versus 38% of those carrying the C allele.
Therefore, this might suggest a protective role for the C allele in the
presence of obesity.